No, as your backpack has a padded laptop section. Therefore, you can't put it in the washing machine. Usually, most stains can be easily removed with a lukewarm soap solution of washing-up liquid or soft soap. Always use a soft cloth, or a sponge, or a small brush (a toothbrush works wonders ;-). However, do not use any aggressive cleaning detergents, such as benzene, ammonia, etc.v